Speed Up your Process Development

SYSTAG System Technik AG


Speed Up your Process Development

SYSTAG’s specialization and expertise in advanced and consistent process automation solutions has made it a preferred partner of the chemical and pharmaceutical industries.

The company offers systems that enhance efficiency and safety at every key stage from development through piloting to production control technology, including all chemical process development aspects, associated thermal safety inspections and scale-up.

Controlled Lab Reactors

Controlled-Lab-Reactors - FlexyCUBE – Modular automated laboratory reactor

FlexyCUBE

Modular automated laboratory reactor

FlexyCUBE is a modular tool engineered to suit all laboratory reactor automation needs. It allows laboratories to use autonomous operation of multiple parallel reactor units from a single PC, using SYSTAG’s proven Windows 7/XP-based software that can manage recipe-controlled automation of experiments.

Reaction Calorimeter

Scale-Up - Calo2310 – Integrating Heat Flow and Balance Calorimetry

Calo2310

Integrating Heat Flow and Balance Calorimetry

Calo2310 provides a unique combination of heat flow and heat balance calorimetry that provides users with more precise and reliable plausibility checks for their analyses.

Scale-Up

Reaction-Calorimeter - FlexyPlant – Modular Concept Raised to Plant Scale

FlexyPlant

Modular Concept Raised to Plant Scale

FlexyPlant combines the modular controlled reaction concept that FlexyCUBE and FlexyPAT bring to the laboratory with the flexibility of the FlexySys control system to provide integrated automation of production scale processes.

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FlexyCUBE

Modular automated laboratory reactor

FlexyCUBE is a modular tool engineered to suit all laboratory reactor automation needs. It allows laboratories to use autonomous operation of multiple parallel reactor units from a single PC, using SYSTAG’s proven Windows 7/XP-based software that can manage recipe-controlled automation of experiments.

FlexyCUBE includes all necessary tools and functions to enable users to simulate complex standalone and parallel chemical synthesis reactions, including hydrogenation, Grignard or Friedel-Crafts reactions, acetylation, nitration and esterification.

It offers a very wide range of applications, with projects being controlled individually or in parallel, for Design of Experiment (DoE) projects.

Functions

The FlexyCUBE reactor unit performs all the core functions demanded by synthesis and screening laboratories:

  • Gravimetric dosing (through use of balance, pump and/or solenoid valve)
  • Accurate reactor or jacket-based temperature control
  • Optimal stirring efficiency–
  • Single-sided (standard) or optional double-sided pH control, with or without mass detection
  • Fractional distillation capability
  • Optimal crystallization performance
  • Safe hydrogenation
  • Easy inertization
  • Simplified calorimetry

Calo2310

Integrating Heat Flow and Balance Calorimetry

Calo2310 provides a unique combination of heat flow and heat balance calorimetry that provides users with more precise and reliable plausibility checks for their analyses. This dynamic reaction calorimeter offers a wide range of applications to enable scientific investigation of:

  • Scale-up & scale-down
  • Thermal risk analysis
  • Kinetics
  • Runaway scenarios
  • Criticality of processes

Functions

Basic Calo2310 functions include controls over a range of reactions; isothermal and non-isothermal, isoperibol and adiabatic; with continuous evaluation right through to reflux, either with or without any calibration.

The system allows gravimetric as well as manual dosing, even of solids, which is constantly temperature-compensated, maintaining overall heat balance between reactor and reflux condenser, with automatic co-determination. All Calo2310 systems incorporate SYSTAG’s automatic ‘Zero Watt’ technology that eliminates the baseline.

These unprecedented additional features guarantee maximum reproducibility and precision regardless of physical influences for all types of reactions, such as:

  • Polymerizations
  • Condensations
  • Hydrogenations/Acetylations
  • Esterifications
  • Non-homogeneous reactions (liquid/gas – liquid/solid)
  • Grignard reactions
FlexyCube
Flexibility and Adaptability

Calo2310 can be supplied with various reactor sizes and shapes to support different applications. The system provides a wide range of measurements and control,

  • Volumetric dosing by injection pump
  • Pressure and vacuum control
  • Gas dosing / hydrogenation
  • Process gas measurement with optional gas-flow-meter FM4
  • Automatic distillation with continuous mass balance

The system can also be tailored to specific key data requirements, with temperature range supported ranging from -80°C to +300°C. Other options include:

  • Temperature resolution TR, TJ, dTRJ, dTC 0.4 mK
  • Sensitivity 100 mW
  • Dynamic reactor greater than 1000 W
  • Dynamic reflux greater than 500 W
  • Compensation of water equivalents throughout the whole temperature range
  • Kinetic step response 10% - 90% in under 90 seconds

FlexyPlant

Modular Concept Raised to Plant Scale

FlexyPlant combines the modular controlled reaction concept that FlexyCUBE and FlexyPAT bring to the laboratory with the flexibility of the FlexySys control system to provide integrated automation of production scale processes.

FlexyPlant provides customers with customized design solutions for the complete automation of kilo lab plants with reactor sizes up to 250 liters. These can be provided as design solutions, including functional control software specifications, user interface, control hardware, input/output lists and circuit diagrams.

Alternatively, FlexyPlant can create a total turnkey production plant, complete with reactors, sensors and fittings, in collaboration with Swiss partners Büchi. FlexyPlant technology is also applicable to pilot plants, special reactors and challenging chemical process technologies such as polymerizations, hydrogenations or thermal separation of substances.

Application

FlexyPlant is SYSTAG’s automation solution to the particular demands imposed by kilo lab and pilot plants, where the quantities of materials used require the process management of a production operation, together with a comprehensive safety concept. At the same time, the operating team must be able to respond quickly and flexibly to any deviation from the defined process.

The provides the final link in a universal control concept that extends from laboratory to pilot plant and production, with consistent look and feel, interchangeable recipes, automatic data acquisition/logging and end-to-end compliance with GMP and CFR 21, Part 11.

It provides centralized control of all special apparatus, including rectification units, hydrogenation autoclaves, and polymerization plants. The FlexySys process control system combines the flexibility of manual operation with the safety, reliability and reproducibility of a recipe-controlled plant.

FlexyPlant
Implementation

Plant specifications are developed in close co-operation with the user. The customer can contact specialists at SYSTAG with professional understanding of the detailed working practices and requirements of process development. In close co-operation with the customer, SYSTAG will produce a detailed specification that will in turn be used as the basis for a tailored FlexyPlant automation solution or a turnkey production plant.

The requirement specification encompasses functional specifications for control software, a practical user interface, selection of control hardware (e.g. Siemens S7, Beckhoff), I/O lists and switch cabinet planning and cable diagrams.

Turnkey systems also include P&I diagrams, peripheral devices such as pumps, scales, sensors, valves, fittings and core hardware including reactors, structural reactor components, templates and Nutsch-type filters with the latter supplied by respected Swiss partner, Büchi.